Investigating how Neurofibromin 2 affects heart failure
The role of Neurofibromin 2 in heart failure
This study is looking at how a protein called Neurofibromin 2 (NF2) affects heart failure by exploring how it helps heart cells produce energy, with the goal of finding new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11095715 on NIH RePORTER |
What this research studies
This research explores the role of Neurofibromin 2 (NF2) in heart failure, focusing on how metabolic processes in the heart can lead to energy deficits and contribute to the disease. The study aims to understand the molecular mechanisms that regulate mitochondrial respiration in heart cells, particularly how NF2 influences the expression of key proteins involved in energy production. By examining the effects of NF2 deletion in heart cells, researchers hope to identify new pathways that could be targeted for more effective treatments for heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure due to metabolic dysfunction.
Not a fit: Patients with heart failure caused by non-metabolic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, mechanism-based therapies for heart failure that address the underlying metabolic issues.
How similar studies have performed: While the specific role of NF2 in heart failure is being explored, similar research has shown promise in understanding metabolic dysfunction in heart diseases.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Del Re, Dominic P — Rutgers Biomedical and Health Sciences
- Study coordinator: Del Re, Dominic P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.