Investigating how neuroactive steroids affect brain receptors
Official title: Studies on G-protein coupled receptors that are activated by neuroactive steroids
Funded at Tufts University Boston · NIH-10939951 · Data updated 2026-11-12
This study is looking at a natural substance in the brain called allopregnanolone, which may help improve anxiety, mood, and seizures, to find new ways to treat conditions like postpartum depression and other mental health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $563,934 |
| NIH project number | 1R01MH137022-01 |
| Project ID | NIH-10939951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing anxiety, depression, or seizure disorders.
✕Less likely to help
Patients with conditions unrelated to neuroactive steroid effects may not benefit from this research.
What this research studies
This research focuses on neuroactive steroids, particularly allopregnanolone, which are produced in the brain and have significant effects on anxiety, seizures, and mood. The study aims to understand how these steroids interact with specific receptors in the brain, potentially leading to new treatments for conditions like postpartum depression. By examining the mechanisms through which these steroids modulate brain activity, the research seeks to uncover new therapeutic targets for various neurological and psychiatric disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for anxiety, depression, and seizure disorders.
How similar studies have gone: Previous studies have shown promise in understanding the effects of neuroactive steroids, indicating potential for success in this area of research.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Moss, Stephen J — Tufts University Boston
- Study coordinator: Moss, Stephen J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.