Investigating how neuro-immune interactions affect migraine triggered by PACAP.
Official title: The role of neuro-immune interactions in PACAP induced migraine
Funded at University of Texas Med Br Galveston · NIH-11009977 · Data updated 2026-11-12
This study is looking at how a special protein called PACAP affects the nervous and immune systems in relation to migraines, with the hope of finding new ways to help people who suffer from migraines feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | January 10, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $449,651 |
| NIH project number | 5R01NS131507-02 |
| Project ID | NIH-11009977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who suffer from chronic migraines and are interested in potential new treatment options.
✕Less likely to help
Patients who do not experience migraines or have other unrelated neurological disorders may not benefit from this research.
What this research studies
This research explores the complex interactions between the nervous and immune systems in relation to migraines, particularly focusing on a neuropeptide called PACAP. By using animal models, the study aims to understand how PACAP influences mast cells and pain receptors, which may contribute to migraine development. The researchers will investigate the role of specific receptors involved in this process and how their activation leads to migraine-like symptoms. This could provide insights into new treatment strategies for migraine sufferers.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing and preventing migraines.
How similar studies have gone: Previous research has shown promising results in understanding neurogenic inflammation and its role in migraine, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Green, Dustin Pepper — University of Texas Med Br Galveston
- Study coordinator: Green, Dustin Pepper
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.