Investigating how neuro-immune interactions affect migraine triggered by PACAP.
The role of neuro-immune interactions in PACAP induced migraine
This study is looking at how a special protein called PACAP affects the nervous and immune systems in relation to migraines, with the hope of finding new ways to help people who suffer from migraines feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11009977 on NIH RePORTER |
What this research studies
This research explores the complex interactions between the nervous and immune systems in relation to migraines, particularly focusing on a neuropeptide called PACAP. By using animal models, the study aims to understand how PACAP influences mast cells and pain receptors, which may contribute to migraine development. The researchers will investigate the role of specific receptors involved in this process and how their activation leads to migraine-like symptoms. This could provide insights into new treatment strategies for migraine sufferers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who suffer from chronic migraines and are interested in potential new treatment options.
Not a fit: Patients who do not experience migraines or have other unrelated neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing and preventing migraines.
How similar studies have performed: Previous research has shown promising results in understanding neurogenic inflammation and its role in migraine, indicating that this approach has potential for success.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Green, Dustin Pepper — University of Texas Med Br Galveston
- Study coordinator: Green, Dustin Pepper
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.