Investigating how Neurexin1 affects goal-directed behavior in neuropsychiatric conditions
Molecular and Circuit Mechanisms of Neurexin1-Mediated Goal-Directed Dysfunction
This study is looking at a protein called Neurexin1α in mice to see how it affects decision-making and behavior in people with neuropsychiatric disorders, with the hope of finding new ways to help those who struggle with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11196755 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Neurexin1α, a protein involved in the organization of synapses, in neuropsychiatric disorders that impair goal-directed behavior. By studying mice with mutations in Neurexin1α, researchers will explore how changes in neural circuits affect decision-making and adaptability in response to rewards and uncertainties. The study employs advanced behavioral assessments and electrophysiological techniques to uncover the molecular and circuit-level mechanisms that contribute to these dysfunctions. Insights gained from this research could lead to better therapeutic strategies for individuals affected by these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neuropsychiatric disorders, particularly those exhibiting symptoms related to goal-directed behavior.
Not a fit: Patients without neuropsychiatric disorders or those not exhibiting goal-directed dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neuropsychiatric disorders characterized by goal-directed dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the role of synaptic proteins in neuropsychiatric conditions, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Fuccillo, Marc V — University of Pennsylvania
- Study coordinator: Fuccillo, Marc V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.