Investigating how Neuregulin-1 protects the brain from damage caused by cerebral malaria
Protective role of Neuregulin-1 against cerebral malaria-induced neuronal injury and behavioral sequelae
This study is looking at how a substance called Neuregulin-1 might help protect children's brains from damage caused by severe malaria, with the hope of finding new ways to treat or prevent these serious effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morehouse School of Medicine NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10813698 on NIH RePORTER |
What this research studies
This research focuses on understanding the protective effects of Neuregulin-1 (NRG1) against brain injury caused by human cerebral malaria, a severe form of malaria that can lead to significant neurological damage in children. The study utilizes various models, including cell cultures and animal models, to explore how NRG1 can mitigate inflammation and restore blood-brain barrier integrity. By identifying the mechanisms through which NRG1 operates, the research aims to develop potential therapeutic strategies for treating cerebral malaria and its aftermath. Patients may benefit from insights gained into how to prevent or reduce brain damage associated with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with cerebral malaria.
Not a fit: Patients who are not affected by cerebral malaria or are older than 21 years may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect children's brains from the damaging effects of cerebral malaria.
How similar studies have performed: Previous research has shown promising results with similar neuroprotective approaches, indicating potential for success in this area.
Where this research is happening
Atlanta, United States
- Morehouse School of Medicine — Atlanta, United States (Active)
Researchers
- Principal investigator: Stiles, Jonathan K. — Morehouse School of Medicine
- Study coordinator: Stiles, Jonathan K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.