Investigating how Neuregulin-1 affects the function of the corpus luteum in reproduction
The role of Neuregulin-1 (NRG1) in corpus luteum (CL) physiology
This study is looking at how a protein called Neuregulin-1 affects the health of the corpus luteum, which is important for keeping a pregnancy going, and it aims to find ways to improve reproductive health by understanding how this protein works with hormones and inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Morehouse School of Medicine NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10640225 on NIH RePORTER |
What this research studies
This research explores the role of Neuregulin-1 (NRG1) in the physiology of the corpus luteum (CL), which is crucial for maintaining pregnancy. The study examines how NRG1 influences the production of progesterone and the overall health of the CL, particularly in response to hormonal signals and inflammatory factors. By understanding these mechanisms, the research aims to identify potential therapeutic targets for improving reproductive outcomes. The approach includes both laboratory experiments and analysis of cellular interactions within the ovarian environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing reproductive challenges, particularly those related to luteal phase defects.
Not a fit: Patients who are not seeking to conceive or have no reproductive health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for reproductive issues related to corpus luteum dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammatory and survival signals in reproductive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Morehouse School of Medicine — Atlanta, United States (Active)
Researchers
- Principal investigator: Chowdhury, Indrajit — Morehouse School of Medicine
- Study coordinator: Chowdhury, Indrajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.