Investigating how netrin1 guides the growth of nerve cells
Assessing the contact-mediated role of netrin1 in axon guidance
This study is looking at a protein called netrin1 that helps guide nerve cells as they grow, and it's for anyone interested in how our nervous system develops and how we might improve treatments for nerve-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10663255 on NIH RePORTER |
What this research studies
This research explores the role of netrin1, a protein that helps direct the growth of nerve cells during development. It focuses on how netrin1 is produced by neural progenitor cells and acts locally to guide axons along specific paths rather than diffusing over long distances. By understanding the mechanisms of axon guidance and the adhesive properties of netrin1, the research aims to uncover new insights into how neural circuits are formed in the embryonic environment. This could lead to advancements in treating conditions related to nerve growth and repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting nerve growth or repair, such as spinal cord injuries or neurodevelopmental disorders.
Not a fit: Patients with fully developed neural systems and no history of nerve-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for repairing nerve damage and treating neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of guidance factors like netrin1 in neural development, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Butler, Samantha J — University of California Los Angeles
- Study coordinator: Butler, Samantha J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.