Investigating how nerve signals contribute to lung scarring in patients with pulmonary fibrosis
Noradrenergic mechanisms of IPF
This study is looking at how certain nerves in the lungs might be making pulmonary fibrosis worse, and it aims to test new medications that could help improve treatment for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11067803 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind pulmonary fibrosis, a condition that leads to severe lung scarring and can worsen patient outcomes. The study aims to explore the role of adrenergic nerves and their signaling in the fibrotic process, particularly in Idiopathic Pulmonary Fibrosis (IPF). By examining how these nerve signals contribute to lung damage and testing the effects of specific medications that block these signals, the research seeks to identify new therapeutic targets for improving patient care. Patients may be involved in trials assessing the effectiveness of these treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Idiopathic Pulmonary Fibrosis or other forms of pulmonary fibrosis.
Not a fit: Patients with non-fibrotic lung conditions or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve lung function and quality of life for patients with pulmonary fibrosis.
How similar studies have performed: Previous studies have shown promising results with similar approaches, indicating that targeting adrenergic signaling may improve outcomes in patients with pulmonary fibrosis.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Herzog, Erica L — Yale University
- Study coordinator: Herzog, Erica L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.