Investigating how nerve remodeling affects lung fibrosis in scleroderma
Macrophage driven, profibrotic adrenergic nerve remodeling in SSc-ILD
This study is looking at how changes in nerves and lung scarring are connected in people with scleroderma, and it will explore the role of a protein called Netrin-1 to see how it might affect lung health, with the help of patient samples and information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10579990 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex interactions between nerve remodeling and lung fibrosis in patients with scleroderma, an autoimmune disease. The study aims to explore the role of a protein called Netrin-1, which is involved in nerve guidance and may influence the behavior of immune cells known as macrophages. By examining these mechanisms, the research seeks to uncover how nerve signals can affect lung injury and repair processes. Patients may be involved in providing samples or data to help elucidate these relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with scleroderma, particularly those experiencing lung-related symptoms.
Not a fit: Patients with scleroderma who do not have lung involvement or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lung fibrosis in scleroderma patients.
How similar studies have performed: While the specific approach of this research is novel, there is growing interest in the role of nerve signaling in immune responses, suggesting potential for success based on related studies.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Herzog, Erica L — Yale University
- Study coordinator: Herzog, Erica L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.