Investigating how nerve activity influences myelin formation
Novel molecular mediators for activity-dependent myelination
This study is looking at how certain molecules help protect nerve fibers in the brain and spinal cord by forming a protective layer called myelin, which is important for conditions like multiple sclerosis, and it hopes to find new ways to improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11081024 on NIH RePORTER |
What this research studies
This research explores the role of specific molecular mediators in the development of myelin sheaths around nerve fibers in the central nervous system. By examining how neuronal activity affects myelination, the study aims to uncover the mechanisms that regulate this process, particularly in the context of spinal cord health and disease. The research utilizes advanced techniques to analyze the interactions between neurons and glial cells, focusing on calcium channels and their impact on myelin development. Patients may benefit from insights that could lead to new treatments for conditions like multiple sclerosis, where myelin is damaged.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with conditions affecting myelin, such as multiple sclerosis or spinal cord injuries.
Not a fit: Patients with conditions unrelated to myelin damage or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for repairing myelin damage in neurological diseases.
How similar studies have performed: Previous research has shown promising results in understanding myelin development, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Sun, Wenjing — Ohio State University
- Study coordinator: Sun, Wenjing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.