Investigating how nerve ablation can help treat high blood pressure
Official title: Evaluating the Mechanisms of Afferent Renal Nerve Ablation as a Treatment for Hypertension
Funded at University of Minnesota · NIH-10917044 · Data updated 2026-11-12
This study is testing a new way to help lower blood pressure for people with hypertension who haven't found relief with regular treatments by looking at a special type of nerve in the kidneys and seeing if removing them can make a difference.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $49,324 |
| NIH project number | 5F30HL167564-02 |
| Project ID | NIH-10917044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with treatment-resistant hypertension who have not responded to lifestyle changes or medication.
✕Less likely to help
Patients with hypertension that is well-controlled through existing therapies may not benefit from this research.
What this research studies
This research explores a new treatment for hypertension by focusing on the role of afferent renal nerves, which are sensory nerves in the kidneys. The study aims to determine whether ablating these nerves can effectively lower blood pressure in patients who do not respond to traditional treatments. Using a novel method developed in the lab, researchers will compare the effects of afferent renal nerve ablation to total renal nerve ablation in a controlled setting. If successful, this approach could offer a new option for patients struggling with high blood pressure.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients with resistant hypertension.
How similar studies have gone: Previous clinical trials have shown that renal nerve ablation can effectively lower blood pressure, suggesting that this approach may also be promising.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: De la Cruz-Lynch, Arthur Trenton — University of Minnesota
- Study coordinator: De la Cruz-Lynch, Arthur Trenton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.