Investigating how neprilysin inhibition affects heart tissue fibrosis
Effect of Neprilysin Inhibition on Myocardial Interstitial Fibrosis
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10801055
This study is looking at how certain changes in heart tissue might affect people with heart failure and aims to find new treatment options by exploring the impact of a specific medication on heart health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10801055 on ClinicalTrials.gov |
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting millions of Americans. It aims to understand how myocardial interstitial fibrosis (MIF), which is caused by factors like hypertension and diabetes, contributes to HFpEF. The study will utilize advanced techniques such as cardiac MRI and large-scale proteomics to explore the effects of neprilysin inhibition on the extracellular matrix in heart tissue. By examining the relationship between neprilysin inhibition and levels of regulatory proteins, the research seeks to identify potential new treatments for this challenging condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with heart failure with preserved ejection fraction, particularly those with underlying conditions like hypertension or diabetes.
Not a fit: Patients who do not have heart failure or those with heart failure with reduced ejection fraction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat or prevent heart failure with preserved ejection fraction.
How similar studies have performed: Previous research has shown promising results with neprilysin inhibition in heart failure treatments, indicating potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CUNNINGHAM, JONATHAN WOO — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: CUNNINGHAM, JONATHAN WOO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.