Investigating how neonatal seizures affect brain injury in newborns
Neuronal Seizure Burden versus Cell Death after Neonatal Brain Injury
This study is looking at how seizures in newborns might affect brain injury caused by a lack of oxygen, using special imaging to see what's happening in real-time in baby mice, with the hope of finding better ways to help babies who have these issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064033 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of neonatal seizures on brain injury caused by hypoxic-ischemic events in newborns. By using advanced imaging techniques, the study aims to monitor seizures and neuronal cell death in real-time in neonatal mice. The goal is to determine whether seizures worsen brain injury or simply indicate its severity. This could lead to better treatment strategies for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns who have experienced hypoxic-ischemic brain injury and are at risk for seizures.
Not a fit: Patients who do not have a history of neonatal brain injury or seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neonatal seizures and better outcomes for infants with brain injuries.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to study brain injuries, but this specific approach is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mcnally, Melanie a — Massachusetts General Hospital
- Study coordinator: Mcnally, Melanie a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.