Investigating how NCAM influences the restructuring of synapses in developing neurons.
Official title: NCAM drives synaptic remodeling in developing GABAergic neurons in C. elegans
Funded at Vanderbilt University · NIH-10993091 · Data updated 2026-11-12
This study is looking at how certain proteins help brain cells called GABAergic neurons change and connect with each other as they grow, using tiny worms to learn more about this process, which could help us understand how our brains develop and work better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | December 1, 2023 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $34,287 |
| NIH project number | 5F31NS134292-02 |
| Project ID | NIH-10993091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals interested in the biological mechanisms of neural development and those affected by neurological conditions.
✕Less likely to help
Patients with established neurological disorders that do not involve developmental aspects may not benefit directly from this research.
What this research studies
This research focuses on understanding the mechanisms behind synaptic remodeling in GABAergic neurons using the model organism C. elegans. The study examines how specific proteins, particularly NCAM-1, play a crucial role in the relocation and assembly of synapses during the development of these neurons. By utilizing advanced techniques like single-cell RNA sequencing, the researchers aim to identify additional factors involved in this process. This work could provide insights into the fundamental aspects of neural circuit development and function.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of neural development, potentially leading to new therapeutic strategies for neurological disorders.
How similar studies have gone: While the specific approach of studying NCAM in C. elegans is novel, similar research has shown success in understanding synaptic mechanisms in other model organisms.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Gailey, Casey — Vanderbilt University
- Study coordinator: Gailey, Casey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.