Investigating how natural antisense RNA affects Alzheimer's disease
THE HUMAN BRAINOME III: EQTL REGULATION BY NATURAL ANTISENSE RNA IN ALZHEIMER S DISEASE
This study is looking at how certain genes might play a role in late-onset Alzheimer's disease by examining a special type of RNA in brain samples, with the hope of finding new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10870083 on NIH RePORTER |
What this research studies
This research explores the genetic factors contributing to late-onset Alzheimer's disease by examining how natural antisense RNA influences gene expression and protein production. Using advanced sequencing technology, the study will analyze RNA from brain samples to identify key genetic variations and their effects on disease pathways. By mapping these relationships, the research aims to uncover new insights into the mechanisms of Alzheimer's and potentially identify targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with late-onset Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with early-onset Alzheimer's disease or those without a genetic predisposition to late-onset Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Alzheimer's disease.
How similar studies have performed: Previous research using similar genomic and transcriptomic approaches has shown promise in understanding complex diseases, suggesting potential for success in this study.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Myers, Amanda J — University of Miami School of Medicine
- Study coordinator: Myers, Amanda J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.