Investigating how nasal immunity and microbiome affect lung health in people with HIV
Official title: HIV-Associated Lung Disease: The Role of Nasal Mucosal Immunity and Microbiome
Funded at Univ of North Carolina Chapel Hill · NIH-11008374 · Data updated 2026-11-12
This study is looking at why people with HIV might have more lung problems and is exploring how the immune system in the nose and the germs that live there can help protect against lung infections, so if you have HIV, your participation could help find ways to improve lung health for you and others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $648,939 |
| NIH project number | 1R01HL176283-01 |
| Project ID | NIH-11008374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may be experiencing or are at risk for chronic lung diseases.
✕Less likely to help
Patients who do not have HIV or those without any respiratory issues may not benefit from this research.
What this research studies
This research focuses on understanding why individuals living with HIV are more susceptible to chronic lung diseases. It examines the role of the nasal mucosal immune system and the microbiome in protecting against respiratory infections and their potential impact on lung health. By comparing the nasal immune environment and microbiome of people living with HIV to those without the virus, the study aims to identify specific changes that could lead to better management of lung diseases. Participants will undergo assessments to track these changes over time.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating lung diseases in people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding the role of the microbiome in respiratory health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Drummond, Michael Bradley — Univ of North Carolina Chapel Hill
- Study coordinator: Drummond, Michael Bradley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.