Investigating how nasal cell genes affect asthma in Hispanic adults
Nasal epithelial epigenomics and transcriptomics and asthma in Hispanic adults
This study is looking at how certain cells in the nose might affect asthma in Hispanic adults, especially those from Puerto Rico and the Dominican Republic, by analyzing samples to find clues that could help improve asthma care for this community.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11111344 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of nasal epithelial cells in asthma among Hispanic adults, particularly those of Puerto Rican and Dominican descent. By examining DNA methylation and gene expression in these cells, the study aims to uncover the biological mechanisms that contribute to asthma and its severity. Participants will be involved in providing nasal samples, which will be analyzed to identify potential biomarkers for asthma. The findings could lead to improved prevention and treatment strategies tailored for this underserved population.
Who could benefit from this research
Good fit: Ideal candidates for this research are Hispanic adults, particularly those of Puerto Rican and Dominican heritage, who have a history of asthma.
Not a fit: Patients who do not identify as Hispanic or do not have asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better asthma management and treatment options specifically for Hispanic adults.
How similar studies have performed: Previous research has successfully identified biomarkers for asthma in children, suggesting that similar approaches may yield valuable insights in adults.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Celedon, Juan Carlos — University of Pittsburgh at Pittsburgh
- Study coordinator: Celedon, Juan Carlos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.