Investigating how nanoscale oligomers affect cell membranes in Huntington's disease
Nanoscopic Membrane Modulations Induced by Nanoscale Oligomers
This study is looking at how tiny clumps of a faulty protein related to Huntington's disease affect brain cells, with the hope of finding ways to protect those cells and improve treatment options for patients.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10790511 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of nanoscale oligomers of the mutant huntingtin protein in Huntington's disease, a severe neurodegenerative disorder. The study aims to explore how these oligomers interact with cell membranes, potentially leading to cellular dysfunction and neuronal death. By examining the lipid specificity of these interactions, the research seeks to uncover why certain cells are more vulnerable to amyloid toxicity than others. Patients may benefit from insights that could lead to targeted therapies aimed at protecting neurons from damage caused by these oligomers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease, particularly those experiencing early to moderate symptoms.
Not a fit: Patients with advanced Huntington's disease or those without a confirmed diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that protect neurons in Huntington's disease.
How similar studies have performed: Previous research has shown promising results in understanding amyloid interactions with cell membranes, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Pan, Jianjun — University of South Florida
- Study coordinator: Pan, Jianjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.