Investigating how NAD metabolism affects aging and disease
NAD Metabolism in Aging and Disease: Dysfunction and Intervention
This study is looking at how changes in a molecule called NAD+ as we age might affect our health, and it’s testing whether boosting NAD+ levels can help improve age-related problems in certain cells, which could lead to new treatments for diseases that come with getting older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10838554 on NIH RePORTER |
What this research studies
This research explores the role of NAD+ metabolism in the aging process and its impact on various diseases. By examining how aging influences NAD+ levels in cells, particularly in genetically altered fibroblasts, the study aims to understand the underlying mechanisms of age-related dysfunctions. The researchers will also evaluate the effects of pharmacological interventions that enhance NAD+ production to see if they can alleviate age-related issues in these cells. This work could provide insights into potential therapeutic strategies for age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals with genetic conditions that affect DNA repair and aging.
Not a fit: Patients who are younger and do not have conditions related to aging or DNA repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve health and longevity by targeting NAD+ metabolism.
How similar studies have performed: Previous research has shown promising results in targeting NAD+ metabolism for age-related conditions, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Yang, Yue — Weill Medical Coll of Cornell Univ
- Study coordinator: Yang, Yue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.