Investigating how NAD+ affects motor neuron health in ALS
NAD+ metabolism and signaling in ALS models
This study is looking at how a substance called NAD+ might help protect nerve cells in people with ALS, and it's using animal models to find new ways to treat the disease that could eventually help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10670737 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of nicotinamide adenine dinucleotide (NAD+) in protecting motor neurons from degeneration in amyotrophic lateral sclerosis (ALS). By studying the interactions between astrocytes and motor neurons in ALS models, the researchers aim to uncover mechanisms that could lead to new therapeutic strategies. The study utilizes rodent models that mimic human ALS to explore how enhancing NAD+ availability can influence disease progression. Patients may benefit from insights gained that could lead to innovative treatments for ALS.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with amyotrophic lateral sclerosis (ALS), including both sporadic and familial cases.
Not a fit: Patients with other neurodegenerative diseases or those without a diagnosis of ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or halt the progression of ALS.
How similar studies have performed: Previous research has shown promising results in understanding the role of NAD+ in neurodegenerative diseases, suggesting potential for success in this area.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Vargas, Marcelo R — University of Wisconsin-Madison
- Study coordinator: Vargas, Marcelo R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.