Investigating how myeloid cells affect memory deficits after radiation treatment in brain tumor models.
Myeloid cells and radiation-induced memory deficits in rodent glioma model: sex and age effects
This study is looking at how radiation therapy affects memory and thinking skills in older and younger mice with brain tumors, and it wants to understand how certain immune cells in the brain might play a role in these changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10874526 on NIH RePORTER |
What this research studies
This research explores the impact of radiation therapy on cognitive function, particularly focusing on how age and sex influence memory deficits in rodent models of glioma. By examining the role of myeloid cells, which are involved in neuroinflammation, the study aims to uncover the biological mechanisms behind cognitive dysfunction following radiation treatment. The researchers will utilize advanced techniques like ATAC sequencing to analyze changes in gene expression and cellular responses in the brain. This work seeks to fill critical gaps in understanding the long-term effects of radiation on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone radiation treatment for brain tumors, particularly children and adolescents.
Not a fit: Patients who have not received radiation therapy or those with cognitive dysfunction from non-radiation-related causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating cognitive deficits in patients undergoing radiation therapy for brain tumors.
How similar studies have performed: While there is existing clinical evidence linking radiation to cognitive deficits, this specific approach using myeloid cells and ATAC sequencing is relatively novel and has not been extensively tested.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Gupta, Nalin — University of California, San Francisco
- Study coordinator: Gupta, Nalin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.