Investigating how myelination affects absence seizures in children
Maladaptive Myelination in Pediatric Epilepsy
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10899450
This study is looking at how the protective covering around nerve fibers might affect absence seizures in kids, using rodent models to see if changes in this covering could help us find better treatments for these seizures.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10899450 on ClinicalTrials.gov |
What this research studies
This research explores the role of myelination, the process of forming a protective sheath around nerve fibers, in the progression of absence seizures in children. It examines how abnormal myelination may contribute to the excessive synchrony of brain networks associated with these seizures. By studying rodent models that mimic childhood absence epilepsy, the research aims to understand the relationship between seizure activity and changes in myelin structure, potentially leading to new treatment strategies. The study utilizes advanced techniques to observe myelin plasticity and its impact on neuronal function.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with absence epilepsy or absence seizure disorder.
Not a fit: Patients with other types of epilepsy or neurological disorders unrelated to absence seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children suffering from absence epilepsy, potentially reducing seizure frequency and severity.
How similar studies have performed: Other research has shown promising results in understanding myelination's role in epilepsy, suggesting that this approach could yield significant insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KNOWLES, JULIET KLASING — STANFORD UNIVERSITY
- Study coordinator: KNOWLES, JULIET KLASING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Absence Seizure Disorder