Investigating how MYC-regulated proteins and splicing affect cancer growth
MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer
['FUNDING_R01'] · JACKSON LABORATORY · NIH-11007244
This study is looking at how a protein called MYC affects the way genes are spliced in breast cancer cells, which might help us understand how tumors grow and resist treatment, with the hope of finding new ways to fight cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-11007244 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how alternative RNA splicing, influenced by the MYC protein, contributes to cancer development, particularly in breast cancer. By examining the splicing factors regulated by MYC, the study aims to identify how these factors and their associated spliced isoforms promote tumor growth and resistance to cell death. The researchers will utilize mammary cell lines to explore the mechanisms behind MYC's regulation of splicing and its impact on cancer cell behavior. This could lead to new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those with tumors exhibiting MYC dysregulation.
Not a fit: Patients with cancers not associated with MYC dysregulation or those without breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer growth and improving treatment outcomes for patients with breast cancer.
How similar studies have performed: Other research has shown promising results in targeting splicing factors in cancer, indicating that this approach has potential for success.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANCZUKOW-CAMARDA, OLGA — JACKSON LABORATORY
- Study coordinator: ANCZUKOW-CAMARDA, OLGA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.