Investigating how MYC activation affects neuroblastoma tumor progression
MYC activation in tumor progression of neuroblastoma
This study is looking at how a protein called MYC affects the growth and return of neuroblastoma tumors, with the goal of finding ways to make current treatments work better for patients with high-risk neuroblastoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10555259 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms behind the progression of neuroblastoma, particularly how the MYC protein influences tumor growth and recurrence in patients. By analyzing patient-derived cell lines, the study aims to identify specific transcription factors and kinases that contribute to the overexpression of MYC in tumors. The research will explore how manipulating these factors can restore sensitivity to existing therapies, potentially leading to improved treatment strategies for high-risk neuroblastoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with high-risk neuroblastoma, particularly those who have experienced disease progression despite current therapies.
Not a fit: Patients with low-risk neuroblastoma or those who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for high-risk neuroblastoma, potentially reducing recurrence rates and improving survival outcomes.
How similar studies have performed: Previous research has shown promising results in targeting MYC-related pathways in other cancers, suggesting that this approach may also be effective in neuroblastoma.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Kang, Min Hee — Texas Tech University Health Scis Center
- Study coordinator: Kang, Min Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.