Investigating how mutations in sperm affect genetic stability across generations
Understanding genomic stability between generations by assessing mutational burdens in single sperms
This study is looking at how changes in sperm DNA might affect the health of future children, especially as fathers get older, by examining individual sperm cells to find patterns that could lead to genetic disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11237283 on NIH RePORTER |
What this research studies
This research focuses on understanding how mutations that occur in sperm can impact genetic stability and potentially lead to disorders in offspring. By analyzing single sperm cells, the study aims to identify patterns of mutations that may be passed down through generations. The approach combines advanced sequencing techniques with computational analysis to detect both clonal and non-clonal mutations. This could provide insights into the risks associated with paternal age and its effects on genetic disorders in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are men of varying ages who are planning to conceive or have concerns about genetic risks to their offspring.
Not a fit: Patients who are not planning to conceive or those without concerns about genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of genetic disorders linked to paternal age and sperm mutations.
How similar studies have performed: Previous research has indicated that understanding clonal mosaic mutations in sperm can provide valuable insights into genetic disorders, suggesting that this approach has potential for success.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Yang, Xiaoxu — University of Utah
- Study coordinator: Yang, Xiaoxu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.