Investigating how mutations in histone proteins contribute to cancer development
Histone fold Mutations in Cancer Pathogenesis
This study is looking at changes in certain proteins that help package DNA in cancer patients to see how these changes might affect the growth of different types of cancer, like lung and bladder cancer, and it could help find new ways to treat these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10914070 on NIH RePORTER |
What this research studies
This research examines genomic datasets from cancer patients to identify recurrent mutations in histone proteins, which are crucial for DNA packaging and gene regulation. By analyzing these mutations, the study aims to understand how they contribute to the development and progression of various cancers, including lung, colorectal, head and neck, and bladder cancers. The researchers utilize advanced techniques, including CRISPR, to explore the functional impact of these mutations on chromatin structure and gene expression. This work could lead to new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with lung, colorectal, head and neck, or bladder cancers who have specific histone mutations.
Not a fit: Patients without cancer or those whose tumors do not exhibit histone mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer mechanisms and the development of targeted therapies for patients with specific histone mutations.
How similar studies have performed: Other research has shown promising results in understanding the role of histone mutations in cancer, indicating that this approach is building on established findings.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Licht, Jonathan D. — University of Florida
- Study coordinator: Licht, Jonathan D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.