Investigating how mutations in histone proteins affect B-cell cancers
Role of novel onco-histone mutations in B-cell malignancies
This study is looking at how certain changes in a protein called linker histone H1 might affect B-cell cancers like Hodgkin's lymphoma, with the goal of finding new treatment options that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10671507 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific mutations in linker histone H1 and their impact on B-cell malignancies, such as Hodgkin's lymphoma and other types of lymphomas. By examining how these mutations influence gene expression and cell behavior, the study aims to uncover mechanisms that lead to the development of cancer in B-cells. The approach involves analyzing genetic and cellular changes in affected patients to identify potential therapeutic targets. Patients may benefit from insights that could lead to new treatment strategies tailored to their specific cancer type.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with Hodgkin's lymphoma or other B-cell malignancies.
Not a fit: Patients with non-B-cell cancers or those without histone mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with B-cell malignancies.
How similar studies have performed: Previous research has shown promising results in understanding the role of histone mutations in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Cesarman, Ethel — Weill Medical Coll of Cornell Univ
- Study coordinator: Cesarman, Ethel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.