Investigating how mutations in a protein affect cancer development
The biochemical, topological and functional impact of cancer-associated Ctcfmutations and their contribution to cancer
This study is looking at how a protein called CTCF helps keep our DNA organized and how changes in this protein might lead to cancer, with the hope that understanding these changes can help develop new treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11015497 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein, CTCF, in organizing the structure of DNA and its impact on gene regulation in cancer. By examining how mutations in CTCF can disrupt normal cellular processes, the study aims to uncover the mechanisms that lead to cancer initiation and progression. The approach involves analyzing chromatin interactions and gene expression patterns in various cell types to identify how these mutations contribute to cancer. Patients may benefit from insights that could lead to new therapeutic strategies targeting these molecular pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cancers associated with B cells, such as B-cell lymphomas.
Not a fit: Patients with cancers unrelated to B cells or those without CTCF mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the molecular mechanisms of cancer driven by CTCF mutations.
How similar studies have performed: Other research has shown promising results in understanding the role of chromatin structure in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Skok, Jane Amanda — New York University School of Medicine
- Study coordinator: Skok, Jane Amanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.