Investigating how mutations in a gene complex affect brain development using yeast models
Modeling THO complex neurodevelopmental disorder mutations in gene expression regulation using budding yeast
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11047545
This study is looking at how changes in a specific protein complex can affect gene expression and potentially lead to brain development issues, using yeast to help us understand these processes better, which could ultimately help people with related conditions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11047545 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how mutations in the THO complex, which is crucial for gene expression regulation, can lead to neurodevelopmental disorders. By using budding yeast as a model organism, the study aims to explore the dynamics of this complex and how disruptions in its function can impact gene expression. The approach involves detailed analysis of RNA metabolism and processing, which are vital for proper neuronal function. Patients may benefit from insights gained into the underlying mechanisms of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders linked to mutations in RNA binding proteins.
Not a fit: Patients with neurodevelopmental disorders not associated with RNA metabolism or THO complex mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neurodevelopmental disorders and potential new therapeutic strategies.
How similar studies have performed: Previous research has shown that studying gene expression regulation in model organisms can yield significant insights into human diseases, suggesting a promising avenue for this investigation.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WECHSLER, THERESA FAITH — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: WECHSLER, THERESA FAITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.