Investigating how mutant KRAS genes affect lung cancer treatment responses
Interrogating the role of mutant KRAS allelic imbalance and co-mutated genes in targeted therapy response of NSCLC
This study is looking at how different changes in the KRAS gene affect non-small cell lung cancer and how these changes might influence how well certain treatments work, with the hope of helping patients get more personalized and effective care based on their unique genetic makeup.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10907465 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mutant KRAS genes and their variations in non-small cell lung cancer (NSCLC) and how these factors influence the effectiveness of targeted therapies. By using precision modeling in mice, the study aims to explore how different genetic profiles can affect tumor growth and response to treatments like KRAS inhibitors. Patients may benefit from insights gained about their specific genetic mutations, which could lead to more personalized and effective treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who have mutations in the KRAS gene.
Not a fit: Patients with lung cancer that does not involve KRAS mutations or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved targeted therapies for lung cancer patients with specific KRAS mutations.
How similar studies have performed: Previous research has shown promising results with targeted therapies for KRAS mutations, indicating potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Diaz, Bianca — Weill Medical Coll of Cornell Univ
- Study coordinator: Diaz, Bianca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.