Investigating how mustard gas affects the eye and its healing process
Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models
This study is looking at how mustard gas can hurt the eyes, especially the front part called the cornea, and it aims to find better ways to treat those injuries for anyone who might be exposed to this harmful substance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10917318 on NIH RePORTER |
What this research studies
This research focuses on understanding the harmful effects of mustard gas on the eye, particularly how it causes injuries to the cornea and other ocular tissues. By using both live animal models and computer simulations, the study aims to explore how mustard vesicants distribute in the eye and the mechanisms behind the resulting injuries. The goal is to identify effective treatment strategies for acute and long-term complications caused by exposure to these toxic agents. This research could provide valuable insights into the healing processes and potential therapies for those affected by mustard gas exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced exposure to mustard gas or similar chemical agents and are suffering from ocular injuries.
Not a fit: Patients with eye injuries not related to chemical exposure or those with pre-existing ocular conditions unrelated to mustard gas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from eye injuries caused by mustard gas exposure.
How similar studies have performed: While research on chemical agents and their effects on the eye is ongoing, this specific approach combining in vivo and in silico models is relatively novel and has not been extensively tested.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Tewari-Singh, Neera — Michigan State University
- Study coordinator: Tewari-Singh, Neera
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.