Investigating how mustard gas affects the eye and its healing process
Official title: Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models
Funded at Michigan State University · NIH-10917318 · Data updated 2026-11-12
This study is looking at how mustard gas can hurt the eyes, especially the front part called the cornea, and it aims to find better ways to treat those injuries for anyone who might be exposed to this harmful substance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $460,271 |
| NIH project number | 5R01EY034140-02 |
| Project ID | NIH-10917318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced exposure to mustard gas or similar chemical agents and are suffering from ocular injuries.
✕Less likely to help
Patients with eye injuries not related to chemical exposure or those with pre-existing ocular conditions unrelated to mustard gas may not benefit from this research.
What this research studies
This research focuses on understanding the harmful effects of mustard gas on the eye, particularly how it causes injuries to the cornea and other ocular tissues. By using both live animal models and computer simulations, the study aims to explore how mustard vesicants distribute in the eye and the mechanisms behind the resulting injuries. The goal is to identify effective treatment strategies for acute and long-term complications caused by exposure to these toxic agents. This research could provide valuable insights into the healing processes and potential therapies for those affected by mustard gas exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from eye injuries caused by mustard gas exposure.
How similar studies have gone: While research on chemical agents and their effects on the eye is ongoing, this specific approach combining in vivo and in silico models is relatively novel and has not been extensively tested.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Tewari-Singh, Neera — Michigan State University
- Study coordinator: Tewari-Singh, Neera
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.