Investigating how muscle training affects exercise performance in patients with pulmonary hypertension
Official title: Peripheral Limitations in Pulmonary Hypertension and Effects of Muscle Training
Funded at Mayo Clinic Rochester · NIH-11062496 · Data updated 2026-11-12
This study is looking at how muscle problems affect exercise in people with Pulmonary Arterial Hypertension (PAH) and will also test if special muscle training can help them exercise better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 10, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $167,741 |
| NIH project number | 5K23HL164901-03 |
| Project ID | NIH-11062496 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Pulmonary Arterial Hypertension who experience exercise intolerance.
✕Less likely to help
Patients with pulmonary hypertension who do not experience exercise limitations may not benefit from this research.
What this research studies
This research focuses on understanding how abnormalities in skeletal muscle impact exercise performance in patients suffering from Pulmonary Arterial Hypertension (PAH). The study aims to measure how well muscles utilize oxygen during physical activity, using advanced techniques to gather accurate data. By comparing patients with PAH to healthy controls, the research seeks to identify specific muscle-related factors that contribute to exercise intolerance. Additionally, a randomized clinical trial will be conducted to evaluate the effects of targeted muscle training on improving exercise capacity in these patients.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise performance and quality of life for patients with pulmonary hypertension.
How similar studies have gone: Preliminary studies have suggested that addressing peripheral muscle abnormalities can improve outcomes in similar patient populations, indicating potential for success in this approach.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Reddy, Yogesh Nellore Vilambi — Mayo Clinic Rochester
- Study coordinator: Reddy, Yogesh Nellore Vilambi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.