Investigating how muscle paralysis affects bone health
Bone Marrow Inflammation and Bone Resorption
This study is looking at how muscle paralysis affects bone health by checking if inflammation in the bone marrow causes bones to weaken, and it’s aimed at finding ways to help prevent bone loss for people with muscle issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10907592 on NIH RePORTER |
What this research studies
This research explores the relationship between muscle paralysis and bone health, specifically how inflammation in the bone marrow can lead to bone loss. Using a mouse model, the study examines how the release of neuropeptides and histamines during muscle paralysis triggers inflammatory signals that promote bone resorption. By understanding these mechanisms, the research aims to identify potential strategies to prevent bone loss associated with neuromuscular dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing muscle paralysis or related neuromuscular disorders.
Not a fit: Patients without muscle paralysis or those with stable bone health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent bone loss in patients with muscle paralysis.
How similar studies have performed: Other research has shown promising results in understanding the link between inflammation and bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Gross, Ted S. — University of Washington
- Study coordinator: Gross, Ted S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.