Investigating how muscle paralysis affects bone health
Official title: Bone Marrow Inflammation and Bone Resorption
Funded at University of Washington · NIH-10907592 · Data updated 2026-11-12
This study is looking at how muscle paralysis affects bone health by checking if inflammation in the bone marrow causes bones to weaken, and it’s aimed at finding ways to help prevent bone loss for people with muscle issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 16, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $379,950 |
| NIH project number | 5R01AR076353-04 |
| Project ID | NIH-10907592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing muscle paralysis or related neuromuscular disorders.
✕Less likely to help
Patients without muscle paralysis or those with stable bone health may not benefit from this research.
What this research studies
This research explores the relationship between muscle paralysis and bone health, specifically how inflammation in the bone marrow can lead to bone loss. Using a mouse model, the study examines how the release of neuropeptides and histamines during muscle paralysis triggers inflammatory signals that promote bone resorption. By understanding these mechanisms, the research aims to identify potential strategies to prevent bone loss associated with neuromuscular dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent bone loss in patients with muscle paralysis.
How similar studies have gone: Other research has shown promising results in understanding the link between inflammation and bone health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Gross, Ted S. — University of Washington
- Study coordinator: Gross, Ted S.
Related research
Other NIH-funded projects on the same topics.
-
Veverimer to reduce acid in diet-related bone loss in adults with osteopenia
A medication called veverimer is being tested in adults with osteopenia to see if it helps reduce bone loss by neutralizing excess acid from the diet without causing extra sodium or potassium problems.
-
How bone-resorbing cells use nutrients to cause bone loss
The team will test whether blocking a key enzyme that processes the amino acid glutamine can slow bone loss caused by overactive bone-resorbing cells, potentially helping people with osteoporosis.
-
How RBP-J controls bone loss in arthritis
This work aims to understand how the protein RBP-J and the enzyme Hs2st1 control inflammation-driven bone loss in people with rheumatoid arthritis.
-
Bone marrow inflammation that leads to bone loss
This work looks at how nerve-driven inflammation in bone marrow causes quick bone loss after muscle paralysis, with the goal of helping people who lose muscle use or have paralysis.
-
How glutamine affects bone cell development and bone loss
This study is looking at how an important nutrient called glutamine affects bone cells that break down bone, which could help us find new ways to treat bone loss conditions like osteoporosis.
-
Understanding how bone cells communicate to improve bone health in older adults
This study is looking at how two important types of bone cells talk to each other to help keep our bones strong, and it aims to find new ways to prevent bone loss as we age, especially for those dealing with osteoporosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.