Investigating how muscle cells behave in insulin resistance and type 2 diabetes
Official title: Determining cell- and spatially-distinct skeletal muscle transcriptional aberrations in insulin resistance and type 2 diabetes
Funded at Adventhealth Orlando · NIH-11009562 · Data updated 2026-11-12
This study is looking at how changes in muscle cells can make it harder for people with type 2 diabetes to use insulin properly, and it hopes to find new ways to help improve insulin sensitivity for better blood sugar control.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | January 9, 2024 |
| Project end | January 8, 2026 |
| Funding year | 2025 |
| Award (this year) | $90,000 |
| NIH project number | 5K99DK135915-02 |
| Project ID | NIH-11009562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with type 2 diabetes or exhibit insulin resistance.
✕Less likely to help
Patients who do not have type 2 diabetes or insulin resistance may not receive any benefit from this research.
What this research studies
This research focuses on understanding the specific changes in muscle cells that contribute to insulin resistance in type 2 diabetes. By using advanced techniques to analyze individual muscle cells and their environments, the study aims to identify the precise transcriptional changes that occur during insulin signaling. This approach allows for a more detailed understanding of how these cellular changes affect glucose uptake in the body. Patients may benefit from insights that could lead to targeted therapies for improving insulin sensitivity.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and glucose uptake in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promise in understanding insulin resistance through cellular analysis, but this study employs novel techniques that have not been widely tested.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Whytock, Katie — Adventhealth Orlando
- Study coordinator: Whytock, Katie
Related research
Other NIH-funded projects on the same topics.
-
How pancreatic alpha cells respond in insulin resistance and type 2 diabetes
This project looks at why pancreatic alpha cells release too much glucagon in adults with insulin resistance or type 2 diabetes.
-
Improving blood flow and insulin response in type 2 diabetes
This study is looking at how a protein called ADAM17 affects blood flow and insulin response in people with type 2 diabetes, to see if blocking this protein can help improve blood sugar control and lower heart risks.
-
Understanding how pancreatic alpha cells respond to insulin resistance and type 2 diabetes
This study is looking at how certain cells in the pancreas behave when someone has type 2 diabetes, especially when the body struggles to use insulin properly, and it aims to find new ways to help manage diabetes better.
-
Using a natural compound to improve insulin sensitivity in type 2 diabetes
This study is looking at a new treatment for type 2 diabetes that targets a protein called galectin-3, using a natural compound called TFD100, to help improve insulin resistance and potentially offer a new option for managing the condition.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.