Investigating how muscle cells behave in insulin resistance and type 2 diabetes
Determining cell- and spatially-distinct skeletal muscle transcriptional aberrations in insulin resistance and type 2 diabetes
This study is looking at how changes in muscle cells can make it harder for people with type 2 diabetes to use insulin properly, and it hopes to find new ways to help improve insulin sensitivity for better blood sugar control.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-11009562 on NIH RePORTER |
What this research studies
This research focuses on understanding the specific changes in muscle cells that contribute to insulin resistance in type 2 diabetes. By using advanced techniques to analyze individual muscle cells and their environments, the study aims to identify the precise transcriptional changes that occur during insulin signaling. This approach allows for a more detailed understanding of how these cellular changes affect glucose uptake in the body. Patients may benefit from insights that could lead to targeted therapies for improving insulin sensitivity.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with type 2 diabetes or exhibit insulin resistance.
Not a fit: Patients who do not have type 2 diabetes or insulin resistance may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and glucose uptake in patients with type 2 diabetes.
How similar studies have performed: Previous research has shown promise in understanding insulin resistance through cellular analysis, but this study employs novel techniques that have not been widely tested.
Where this research is happening
Orlando, United States
- Adventhealth Orlando — Orlando, United States (Active)
Researchers
- Principal investigator: Whytock, Katie — Adventhealth Orlando
- Study coordinator: Whytock, Katie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.