Investigating how multi-omics approaches can improve HIV treatment and vaccination.
Official title: Multi-Omics Core
Funded at Beth Israel Deaconess Medical Center · NIH-11084513 · Data updated 2026-11-12
This study is looking at how certain antibodies and vaccines work against HIV by examining patient samples to better understand the immune responses, which could help improve treatments for people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 11, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $239,365 |
| NIH project number | 5P01AI177687-03 |
| Project ID | NIH-11084513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are undergoing treatment or are part of vaccination programs.
✕Less likely to help
Patients who are not infected with HIV or those who are not involved in treatment or vaccination efforts may not benefit from this research.
What this research studies
This research focuses on using advanced multi-omics techniques to analyze the mechanisms behind the effectiveness of broadly neutralizing antibodies (bNAb) and vaccines against HIV. By employing various genomic methodologies, including ATAC-seq and RNA-seq, as well as spatial profiling techniques, the project aims to understand the cellular and molecular responses to HIV interventions. Patients' samples will be analyzed to identify specific immune responses and viral characteristics, which could lead to improved treatment strategies. The research will also involve collaboration with computational analysis experts to deepen the understanding of these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for HIV, potentially improving patient outcomes significantly.
How similar studies have gone: Previous research using multi-omics approaches has shown promise in understanding complex diseases, suggesting that this approach could yield valuable insights for HIV treatment.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Jiang, Sizun — Beth Israel Deaconess Medical Center
- Study coordinator: Jiang, Sizun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.