Investigating how mucin proteins influence lung cancer development
Effects of Polymeric Mucin Expression on Lung Carcinogenesis
This study is looking at how certain proteins in the lungs might affect the growth of a type of lung cancer called adenocarcinoma, especially in people with a specific gene mutation, to help find new ways to treat this disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10881758 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific mucin proteins, MUC5AC and MUC5B, in the development of lung adenocarcinoma (LUAD), a common and aggressive form of lung cancer. The study aims to uncover how these mucins contribute to tumor growth and aggressiveness, particularly in patients with mutations in the KRAS gene. By using mouse models, researchers will explore the effects of these mucins on tumor size and number, as well as the underlying molecular mechanisms involved. This could lead to new insights into potential therapeutic targets for LUAD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung adenocarcinoma, particularly those with KRAS mutations.
Not a fit: Patients with lung cancer types other than adenocarcinoma or those without KRAS mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for lung adenocarcinoma, potentially enhancing survival rates for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of mucins in cancer biology, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Evans, Christopher M — VA Eastern Colorado Health Care System
- Study coordinator: Evans, Christopher M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.