Investigating how mTOR signaling affects brain development in autism
Official title: Regulation of mTOR signaling in the developing cerebral cortex as a point of convergence for multiple autism risk factors
Funded at Seattle Children's Hospital · NIH-11077352 · Data updated 2026-11-12
This study is looking at how certain genetic changes might affect brain development and behavior in autism, and it hopes to find new ways to help improve brain function for those with autism and related challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | November 20, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $415,863 |
| NIH project number | 5R01MH108519-11 |
| Project ID | NIH-11077352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, particularly those with known genetic mutations affecting mTOR signaling.
✕Less likely to help
Patients without autism spectrum disorder or those whose conditions are unrelated to mTOR signaling may not benefit from this research.
What this research studies
This research focuses on understanding the role of mTOR signaling in the developing brain, particularly how it relates to autism spectrum disorder (ASD) and intellectual disabilities. The study examines genetic mutations, specifically in the DYRK1A gene, that may lead to brain growth issues and behavioral deficits associated with ASD. By using mouse models, researchers aim to uncover the mechanisms behind these mutations and explore potential treatments that could enhance mTOR signaling to improve brain development and function. Patients may benefit from insights that could lead to targeted therapies for ASD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain development and cognitive function in individuals with autism.
How similar studies have gone: Previous research has shown promising results in understanding mTOR signaling in relation to autism, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Page, Damon Theron — Seattle Children's Hospital
- Study coordinator: Page, Damon Theron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.