Investigating how mTOR activation affects blood vessel remodeling in lung disease.
Role of mTOR Hyperactivation in Pulmonary Vascular Remodeling
This study is looking at how a specific pathway in our cells might affect blood vessel changes in people with pulmonary hypertension, with the hope of finding new ways to help improve treatments for this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10865916 on NIH RePORTER |
What this research studies
This research focuses on pulmonary hypertension, a serious lung condition that leads to changes in blood vessel structure and function. The study aims to understand the role of the mTOR signaling pathway in these changes, particularly how its hyperactivation in certain cells can influence the behavior of blood vessel cells. By examining these cellular interactions, the research seeks to uncover new therapeutic targets that could improve treatment options for patients with pulmonary hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension, particularly those with pulmonary arterial hypertension.
Not a fit: Patients with pulmonary hypertension caused by factors unrelated to mTOR signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively target the underlying mechanisms of pulmonary hypertension, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting the mTOR pathway for various diseases, suggesting potential success for this approach in pulmonary hypertension.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lin, Susan M — University of Pennsylvania
- Study coordinator: Lin, Susan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.