Investigating how mRNA modifications affect cancer
Role of the Epitranscriptome in Cancer
This study is looking at how a specific change in the genetic material of cancer cells might affect their behavior, using samples from lung and colon cancer, to find new ways to treat cancer more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11241431 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mRNA methylation in cancer, which has not been thoroughly explored. The team will analyze primary human lung and colon cancer samples alongside normal tissues to map the epitranscriptome. They will investigate how changes in mRNA methylation influence cancer cell behavior and will screen for small molecules that can inhibit specific mRNA methyltransferases. The ultimate goal is to identify new therapeutic targets that could lead to more effective cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals diagnosed with lung or colon adenocarcinomas.
Not a fit: Patients with cancers other than lung or colon adenocarcinomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer therapies that target mRNA modifications, potentially improving treatment outcomes for patients.
How similar studies have performed: While the exploration of the epitranscriptome is a relatively novel approach, previous research has shown promise in targeting epigenetic modifications in cancer treatment.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Gregory, Richard I. — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gregory, Richard I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.