Investigating how mosquito immune systems fight infections
Official title: The immune serine protease pathways in Anopheles gambiae
Funded at Oklahoma State University Stillwater · NIH-10996162 · Data updated 2026-11-12
This study is looking at how certain mosquitoes fight off malaria germs and aims to find ways to boost their immune system to help reduce the spread of malaria.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project start | December 7, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $222,900 |
| NIH project number | 5R21AI180325-02 |
| Project ID | NIH-10996162 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in malaria prevention and control, particularly those living in malaria-endemic regions.
✕Less likely to help
Patients who are not affected by malaria or do not live in areas where malaria is a concern may not benefit from this research.
What this research studies
This research focuses on the immune responses of the Anopheles gambiae mosquito, particularly how it defends against pathogens like malaria parasites. The study examines the role of serine proteases in activating immune proteins that help the mosquito encapsulate and kill these infectious agents. By producing and testing various proteins in a laboratory setting, the researchers aim to understand the mechanisms behind these immune responses and how they can be enhanced. This could lead to new strategies for controlling malaria transmission.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for controlling malaria by enhancing mosquito immunity.
How similar studies have gone: Other research has shown promise in enhancing insect immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
-
Oklahoma State University Stillwater
Stillwater, United States Active
Researchers
- Principal investigator: Jiang, Haobo — Oklahoma State University Stillwater
- Study coordinator: Jiang, Haobo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.