Investigating how molecular signals affect aortic valve development and defects.
Molecular signaling in aortic valve development and congenital aortic valve defect
This study is looking into the genetic reasons behind a heart condition called bicuspid aortic valve, which affects some people from birth, and it aims to find ways to prevent or treat problems that can come from it by using specially modified mice to see how heart valves form during development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11070214 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and molecular mechanisms that lead to congenital aortic valve defects, particularly the bicuspid aortic valve (BAV), which affects about 2% of the population. By using animal models, specifically genetically modified mice, the study aims to explore how disruptions in cell signaling during embryonic development can result in abnormal valve formation. The goal is to identify potential therapeutic targets that could prevent or treat complications associated with BAV, such as calcific aortic valve disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with congenital aortic valve defects, particularly those with bicuspid aortic valve.
Not a fit: Patients with normal aortic valve anatomy or those without congenital heart defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital aortic valve defects and their associated complications.
How similar studies have performed: Previous research has shown success in using animal models to study congenital heart defects, indicating that this approach has potential for yielding valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Zhou, Bin — University of Chicago
- Study coordinator: Zhou, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.