Investigating how modifications to a protein affect its structure and role in diseases like Parkinson's.
Combinatorial effects of PTMs on a-Synuclein structure function and aggregation
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10694546
This study is looking at a protein related to Parkinson's disease to see how different changes to it can affect its behavior, which might help us understand the disease better and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10694546 on ClinicalTrials.gov |
What this research studies
This research focuses on α-Synuclein, a protein linked to Parkinson's disease, and how various chemical modifications to it can influence its structure and function. The team will explore how these modifications affect the protein's ability to aggregate, which is crucial for understanding different forms of synucleinopathies. By using advanced techniques in protein synthesis and biophysics, the researchers aim to uncover the complex interactions between multiple modifications and their collective impact on the protein's behavior in cells. This could lead to better insights into the mechanisms of disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or other synucleinopathies.
Not a fit: Patients with conditions unrelated to α-Synuclein or those without neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Parkinson's disease and related disorders.
How similar studies have performed: Previous research has shown that understanding protein modifications can lead to significant advancements in treating neurodegenerative diseases, indicating a promising avenue for this investigation.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RHOADES, ELIZABETH — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: RHOADES, ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.