Investigating how modifications of the B7-H4 protein affect breast cancer treatment and progression
Targeting posttranslational modifications of B7-H4 in carcinogenesis and therapy
This study is looking at how certain changes to a protein called B7-H4 might affect breast cancer and how well treatments work, with the hope of finding ways to boost the immune system's fight against tumors and improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11045026 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific chemical changes to the B7-H4 protein in breast cancer development and treatment responses. By examining how glycosylation and ubiquitination of B7-H4 influence its function, the study aims to uncover mechanisms that could improve the effectiveness of breast cancer therapies. Patients may benefit from insights gained about how to enhance the immune response against tumors and improve treatment outcomes. The research employs advanced biochemical techniques to analyze protein interactions and their effects on cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with breast cancer, particularly those with triple-negative breast cancer.
Not a fit: Patients with non-breast cancer types or those who do not have any form of cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer by targeting the B7-H4 protein to enhance immune responses.
How similar studies have performed: Previous research has shown promising results in targeting immune checkpoint proteins for cancer therapy, indicating potential success for this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wan, Yong — Emory University
- Study coordinator: Wan, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.