Investigating how modifiable risk factors affect midlife cognition in diverse populations
Official title: Modifiable risk factors and midlife cognition in diverse populations: a pooled cohort study
Funded at University of California, San Francisco · NIH-10887288 · Data updated 2026-11-12
This study is looking at how certain lifestyle choices and health factors can affect memory and thinking skills as people reach middle age, especially in different racial and ethnic groups, to help find ways to prevent Alzheimer's and related conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $122,756 |
| NIH project number | 1K99AG083211-01A1 |
| Project ID | NIH-10887288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 40-65 years, particularly those from diverse racial and ethnic backgrounds who may be at risk for cognitive decline.
✕Less likely to help
Patients outside the age range of 40-65 years or those not at risk for cognitive decline may not benefit from this research.
What this research studies
This research focuses on understanding how modifiable risk factors influence cognitive decline during midlife, particularly among diverse racial and ethnic groups. It aims to identify high-risk individuals and explore the mechanisms behind cognitive disparities related to Alzheimer's Disease and related dementias. By analyzing data from three longitudinal cohort studies, the research seeks to uncover the impact of these risk factors on cognitive health and the underlying biological pathways involved. The goal is to inform prevention strategies that can be tailored to diverse populations.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for cognitive decline in midlife, particularly for underrepresented populations.
How similar studies have gone: Previous research has shown success in identifying modifiable risk factors for cognitive decline, making this approach both relevant and promising.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Jiang, Xiaqing — University of California, San Francisco
- Study coordinator: Jiang, Xiaqing
Related research
Other NIH-funded projects on the same topics.
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Modifiable risk factors and midlife thinking and memory in diverse groups
A study to understand how manageable lifestyle factors affect thinking skills in midlife adults from diverse backgrounds.
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Menopause, aging and brain health: how midlife changes affect Alzheimer’s risk
This study follows women who were part of a large midlife health study to see how menopause and related factors relate to brain biomarkers and memory later in life.
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Midlife memory and dementia risk in Kenyan adults
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Lifelong factors affecting brain health in type 1 diabetes (CLARiFY)
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Understanding midlife brain health in different communities
This project looks at how lifestyle choices and health conditions in middle age might affect brain health later in life, especially for diverse groups of people.
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Investigating risk factors for Alzheimer's disease and related dementias in Kenyan adults.
This study is looking at what might increase the chances of developing Alzheimer's and related dementias in Kenyan adults aged 35 to 43, by exploring how their health, education, and social attitudes have changed since childhood.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.