Investigating how mobile genetic elements contribute to human cancers
Mobile element mutagenesis as a driver of human cancers
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10894056
This study is looking at how certain genetic pieces called LINE-1 elements might affect cancer by changing genes in tumors, and it's for anyone interested in understanding more about how these elements work in our bodies and their role in cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10894056 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of LINE-1 (L1) elements, which are mobile genetic elements that can insert themselves into the human genome. Recent findings suggest that these elements may be active in adult tissues, including tumors, potentially leading to mutations in cancer-related genes. The research will involve creating a resource of these L1 elements and studying their expression and regulation in various human tissues and tumors. By exploring how these elements contribute to cancer development, the research aims to uncover new insights into cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with various types of cancers, particularly those involving the brain and epithelial tissues.
Not a fit: Patients with cancers that do not involve the activation of LINE-1 elements or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer prevention and treatment by targeting the mechanisms of L1 element mobilization.
How similar studies have performed: While the role of LINE-1 elements in cancer is a relatively novel area of investigation, preliminary studies have shown promising results regarding their involvement in tumorigenesis.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEVINE, SCOTT E — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: DEVINE, SCOTT E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Genes, Cancer Suppressor Genes, Cancer-Promoting Gene, Cancers