Investigating how MKP5 regulates heart signaling and fibrosis
MKP5 allostery in MAPK regulation and signaling in the heart
This study is looking at a protein called MKP5 that affects how the heart works, especially in conditions like heart failure, and aims to find new treatments by discovering small molecules that can help control this protein's activity for better heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11001113 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of MKP5, a protein that regulates signaling pathways in the heart, particularly in relation to cardiac fibrosis and heart failure. The study explores how MKP5 interacts with other proteins to control the duration and intensity of heart signaling. By using advanced techniques, including high-throughput screening and structural analysis, the researchers aim to identify small molecules that can inhibit MKP5's activity, potentially leading to new treatments for heart conditions. Patients may benefit from insights gained about MKP5's role in heart disease and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of or suffering from cardiac fibrosis or heart failure.
Not a fit: Patients with heart conditions unrelated to MKP5 or those who do not have cardiac fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce cardiac fibrosis and heart failure.
How similar studies have performed: Previous research has shown promise in targeting similar proteins for therapeutic purposes, indicating potential for success in this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Bennett, Anton M — Yale University
- Study coordinator: Bennett, Anton M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.