Investigating how Mitofusin 2 regulates mitochondrial function in heart disease
Official title: Mitofusin 2 as a Nodal Regulator of Mitochondrial Function in Cardiomyopathy
Funded at Washington University · NIH-11005299 · Data updated 2026-11-12
This study is looking at how a protein called Mitofusin 2 helps heart cells use energy, especially when the heart is not working well, and it hopes to find new ways to improve heart health for people with heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $979,650 |
| NIH project number | 5R35HL171080-02 |
| Project ID | NIH-11005299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with cardiomyopathy or related cardiac conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those without any form of heart disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of Mitofusin 2 in managing mitochondrial function within heart cells, particularly during conditions like cardiomyopathy. The study explores how heart cells transition their energy sources from carbohydrates to fatty acids and how this process is disrupted in heart disease. By examining the mechanisms of mitochondrial replacement and dynamics, the research aims to uncover potential therapeutic targets for improving heart function. Patients may benefit from insights that could lead to new treatments for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve heart function and recovery in patients with cardiomyopathy.
How similar studies have gone: Previous studies have shown promise in understanding mitochondrial dynamics in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Dorn, Gerald W. — Washington University
- Study coordinator: Dorn, Gerald W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.