Investigating how mitochondrial transport affects neuroinflammation and amyloid buildup in Alzheimer's disease
Neuronal mitochondrial transport-linked neuroinflammation and amyloid pathology in Alzheimer's disease
This study is looking at how problems with tiny energy factories in brain cells, called mitochondria, might contribute to memory loss in Alzheimer's disease, and it aims to find ways to help keep these cells healthy and improve brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10467803 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mitochondrial dysfunction and synaptic damage in Alzheimer's disease. It examines how the transport of mitochondria to synapses is affected by amyloid-β peptide accumulation, which is a key feature of Alzheimer's pathology. The study aims to explore the mechanisms behind impaired mitochondrial transport and its impact on neuroinflammation and cognitive decline. By using mouse models, the research seeks to identify potential strategies to mitigate these effects and improve neuronal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance mitochondrial function and reduce neuroinflammation in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yan, Shirley Shidu — Columbia University Health Sciences
- Study coordinator: Yan, Shirley Shidu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.