Investigating how mitochondrial stress affects aging and degenerative diseases
Official title: A novel mitochondria-to-lysosome stress signaling pathway in degenerative disease and aging
Funded at Upstate Medical University · NIH-11092917 · Data updated 2026-11-12
This study is looking at how problems with tiny parts of our cells called mitochondria can affect another part called lysosomes, especially as we age or deal with diseases like Alzheimer's and ALS, to find new ways to help improve health for people facing these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $399,350 |
| NIH project number | 5R01AG082803-03 |
| Project ID | NIH-11092917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with age-related degenerative diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.
✕Less likely to help
Patients with acute conditions unrelated to aging or mitochondrial dysfunction may not benefit from this research.
What this research studies
This research explores the relationship between mitochondrial stress and lysosomal function in the context of aging and degenerative diseases. By examining how mitochondrial dysfunction can lead to cellular stress and impact overall cell health, the study aims to uncover new mechanisms that contribute to conditions like Alzheimer's disease and amyotrophic lateral sclerosis. The research combines expertise in mitochondrial biology and lysosomal biochemistry to understand these complex interactions. Patients may benefit from insights that could lead to new therapeutic strategies targeting these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related diseases and improve the quality of life for affected patients.
How similar studies have gone: While the specific approach of this research is novel, there have been successful studies exploring mitochondrial and lysosomal interactions in other contexts.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Chen, Xin Jie — Upstate Medical University
- Study coordinator: Chen, Xin Jie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.