Investigating how mitochondrial stress affects aging and cell aging processes
The role of sub-lethal mitochondrial apoptotic stress in cellular senescence
This study is looking at how stress in tiny parts of our cells called mitochondria can affect aging, and it's for anyone interested in finding ways to help people age healthier and reduce age-related illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10876474 on NIH RePORTER |
What this research studies
This research explores the connection between mitochondrial stress and cellular aging, focusing on how certain stress responses in mitochondria can lead to cellular senescence, a key factor in aging. The team will conduct laboratory experiments to understand the mechanisms behind this process, particularly how mitochondrial outer membrane permeability (MOMP) can occur without causing cell death. By studying these cellular changes, the research aims to identify potential targets for therapies that could promote healthier aging and mitigate age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those interested in interventions that promote healthy aging.
Not a fit: Patients with acute mitochondrial diseases or those not experiencing age-related cellular changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help delay aging and improve health in older adults.
How similar studies have performed: Previous research has shown promising results in targeting cellular senescence to improve health outcomes, suggesting that this approach could be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Passos, Joao — Mayo Clinic Rochester
- Study coordinator: Passos, Joao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.